For research use only. Not for therapeutic Use.
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity[1].
PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR)[1].
PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ[1].
| Catalog Number | I034543 |
| CAS Number | 1310744-67-2 |
| Synonyms | (5Z)-5-[(4-aminophenyl)methylidene]-2-imino-1,3-thiazolidin-4-one |
| Molecular Formula | C10H9N3OS |
| Purity | ≥95% |
| InChI | InChI=1S/C10H9N3OS/c11-7-3-1-6(2-4-7)5-8-9(14)13-10(12)15-8/h1-5H,11H2,(H2,12,13,14)/b8-5- |
| InChIKey | QXOIZYPBCJHYLN-YVMONPNESA-N |
| SMILES | C1=CC(=CC=C1C=C2C(=O)NC(=N)S2)N |
| Reference | [1]. Atsushi Shibata , et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18. |
