For research use only. Not for therapeutic Use.
PG-11047 (CGC-11047) is a polyamine analogue. PG-11047 can be used for the research of breast cancer[1].
PG-11047 (13 nM-5 mM; 72 h) inhibit growth of members of the panel of breast cell lines varied over a wide range, with basal-like cell lines being inhibited at lower concentrations than the luminal cell lines[1].
PG-11047 (0.3, 10, 300 μM; 48 h, 72 h) shows a significant decrease in S phase fraction at doses that produced little apoptosis[1].
| Catalog Number | I042273 |
| CAS Number | 308145-19-9 |
| Synonyms | (Z)-N,N’-bis[3-(ethylamino)propyl]but-2-ene-1,4-diamine |
| Molecular Formula | C14H32N4 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H32N4/c1-3-15-11-7-13-17-9-5-6-10-18-14-8-12-16-4-2/h5-6,15-18H,3-4,7-14H2,1-2H3/b6-5- |
| InChIKey | XFWLTFZLLXVKDY-WAYWQWQTSA-N |
| SMILES | CCNCCCNCC=CCNCCCNCC |
| Reference | [1]. Wen-Lin Kuo, et al. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14;7:77. |
