For research use only. Not for therapeutic Use.
PG-11047 (CAT: I005998) is a synthetic polyamine analogue that functions as a nonfunctional competitor of the natural polyamine spermine, disrupting polyamine metabolism critical for cell growth and survival. By mimicking spermine without supporting its biological functions, PG-11047 downregulates polyamine biosynthesis and uptake pathways, leading to inhibition of tumor cell proliferation. It has demonstrated broad-spectrum anticancer activity across various tumor types, including lung, colon, prostate, and breast cancers. PG-11047 is also known to enhance the efficacy of other anticancer therapies. It is a valuable agent for research in polyamine-targeted cancer treatment and tumor growth regulation.
| CAS Number | 206991-64-2 |
| Synonyms | (Z)-N,N’-bis[3-(ethylamino)propyl]but-2-ene-1,4-diamine;tetrahydrochloride |
| Molecular Formula | C14H36Cl4N4 |
| Purity | ≥95% |
| IUPAC Name | (Z)-N,N'-bis[3-(ethylamino)propyl]but-2-ene-1,4-diamine;tetrahydrochloride |
| InChI | InChI=1S/C14H32N4.4ClH/c1-3-15-11-7-13-17-9-5-6-10-18-14-8-12-16-4-2;;;;/h5-6,15-18H,3-4,7-14H2,1-2H3;4*1H/b6-5-;;;; |
| InChIKey | MNJCMBNLXQCNHO-YGGCHVFLSA-N |
| SMILES | CCNCCCNCC=CCNCCCNCC.Cl.Cl.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
