PGAM1-IN-2

• CAT Number: I018954
• CAS Number: 2438637-66-0
• Molecular Formula: C25H16N2O7S
• Molecular Weight: 488.47
• Purity: ≥95%
• Synonyms: N-(1-hydroxy-7-nitro-9-oxoxanthen-3-yl)-4-phenylbenzenesulfonamide
• InChI: InChI=1S/C25H16N2O7S/c28-21-12-17(13-23-24(21)25(29)20-14-18(27(30)31)8-11-22(20)34-23)26-35(32,33)19-9-6-16(7-10-19)15-4-2-1-3-5-15/h1-14,26,28H
• InChIKey: BRBFEAYMCMDULD-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)NC3=CC(=C4C(=C3)OC5=C(C4=O)C=C(C=C5)[N+](=O)[O-])O

PGAM1-IN-2 is a phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC50 of 2.1 μM[1].
PGAM1-IN-2 (Compound 15h) inhibits H1299 proliferation with an IC50 of 33.8±6.1 μM[1].

Reference

[1]. Wang P, et al. The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors. Molecules. 2018 Jun 8;23(6). pii: E1396.
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