PGL-135

For research use only. Not for therapeutic Use.

  • CAT Number: I034553
  • CAS Number: 26278-83-1
  • Molecular Formula: C9H10N2OS
  • Molecular Weight: 194.25
  • Purity: 98%
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PGL-135 is a Polyglutamine Aggregation Inhibitor


Catalog Number I034553
CAS Number 26278-83-1
Synonyms

PGL-135; PGL135; PGL 135

Molecular Formula C9H10N2OS
Purity 98%
Solubility To be determined
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 2-Amino-4,7-dimethyl-6-benzothiazolol
InChI InChI=1S/C9H10N2OS/c1-4-3-6(12)5(2)8-7(4)11-9(10)13-8/h3,12H,1-2H3,(H2,10,11)
InChIKey RUTNKAMSWIPHJW-UHFFFAOYSA-N
SMILES OC1=CC(C)=C2N=C(N)SC2=C1C
Reference

1: Hockly E, Tse J, Barker AL, Moolman DL, Beunard JL, Revington AP, Holt K, Sunshine S, Moffitt H, Sathasivam K, Woodman B, Wanker EE, Lowden PA, Bates GP. Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington’s disease. Neurobiol Dis. 2006 Jan;21(1):228-36. doi: 10.1016/j.nbd.2005.07.007. Epub 2005 Aug 18. PMID: 16111888.
2: Lazarev VF, Benken KA, Semenyuk PI, Sarantseva SV, Bolshakova OI, Mikhaylova ER, Muronetz VI, Guzhova IV, Margulis BA. GAPDH binders as potential drugs for the therapy of polyglutamine diseases: design of a new screening assay. FEBS Lett. 2015 Feb 27;589(5):581-7. doi: 10.1016/j.febslet.2015.01.018. Epub 2015 Jan 24. PMID: 25625921.
3: Hands S, Sajjad MU, Newton MJ, Wyttenbach A. In vitro and in vivo aggregation of a fragment of huntingtin protein directly causes free radical production. J Biol Chem. 2011 Dec 30;286(52):44512-20. doi: 10.1074/jbc.M111.307587. Epub 2011 Oct 7. PMID: 21984825; PMCID: PMC3247975.

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