For research use only. Not for therapeutic Use.
PH-002（Cat No.:I019803） is an inhibitor of apolipoprotein (apo) E4 intraneuromolecular interactions with an IC50 (FRET) of 116 nM. PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus.
| Catalog Number | I019803 |
| CAS Number | 1311174-68-1 |
| Molecular Formula | C₂₇H₃₃N₅O₄ |
| Purity | ≥95% |
| Storage | 2-8°C |
| IUPAC Name | tert-butyl 4-[[4-[[2-(3-methyl-4-oxophthalazin-1-yl)acetyl]amino]phenyl]methyl]piperazine-1-carboxylate |
| InChI | InChI=1S/C27H33N5O4/c1-27(2,3)36-26(35)32-15-13-31(14-16-32)18-19-9-11-20(12-10-19)28-24(33)17-23-21-7-5-6-8-22(21)25(34)30(4)29-23/h5-12H,13-18H2,1-4H3,(H,28,33) |
| InChIKey | GSXXTLWPQMHHDJ-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCN(CC1)CC2=CC=C(C=C2)NC(=O)CC3=NN(C(=O)C4=CC=CC=C43)C |
| Reference | [1]. Brodbeck J, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13;286(19):17217-26.<br>[2]. Chen HK, et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17;287(8):5253-66. |
