For research use only. Not for therapeutic Use.
Potent and selective α7 nicotinic acetylcholine receptor (nAChR) agonist, which is characterized by rapid brain penetration and high oral bioavailability; a potential treatment of cognitive deficits in schizophrenia
| Catalog Number | R051806 |
| CAS Number | 478148-58-2 |
| Molecular Formula | C15H17N3O2.2HCl |
| Purity | ≥95% |
| IUPAC Name | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide;dihydrochloride |
| InChI | InChI=1S/C15H17N3O2.2ClH/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18;;/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19);2*1H/t13-;;/m0../s1 |
| SMILES | C1CN2CCC1[C@H](C2)NC(=O)C3=NC=C4C(=C3)C=CO4.Cl.Cl |
| Reference | DG Wishka et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive (…). J. Med. Chem. 2006, 49(14), 4425-4436.
PR Krafft et al. PHA-543613 Preserves Blood–Brain Barrier Integrity After Intracerebral Hemorrhage in Mice. Stroke, 2013, 44(6), 1743-1747. |
