PHA-767491 hydrochloride

• CAT Number: I005601
• CAS Number: 942425-68-5
• Molecular Formula: C12H11N3O.HCl
• Molecular Weight: 249.70
• Purity: ≥95%
• Synonyms: PHA767491 hydrochloride; PHA-767491 hcl
• Target: Cdc7/CDK9
• Solubility: DMSO: ＜ 9 mg/mL
• Storage: 3 years -20C powder
• IC50: 10 nM(Cdc7); 34 nM(Cdk9) Target: Cdc7/CDK9
• IUPAC Name: 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one;hydrochloride
• InChI: InChI=1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H
• InChIKey: IMVNFURYBZMFDZ-UHFFFAOYSA-N
• SMILES: C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3.Cl

PHA-767491 hydrochloride（Cat No.:I005601）is a selective inhibitor of the protein kinase GSK-3 (glycogen synthase kinase 3), which is involved in numerous cellular processes, including glycogen metabolism, cell differentiation, and the regulation of signaling pathways related to cancer and neurodegenerative diseases. By inhibiting GSK-3, PHA-767491 hydrochloride can enhance Wnt signaling and promote neuroprotection, making it a candidate for therapeutic applications in conditions such as Alzheimer’s disease and various cancers. Ongoing research is focused on its pharmacological properties, safety profile, and potential clinical uses to leverage its beneficial effects in targeted therapies.

Reference

[1]. Natoni, Alessandro; Murillo, Laura S.; Kliszczak, Anna E. et al. Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells. Molecular Cancer Therapeutics (2011), 10(9), 1624-1634. 


[2]. Swords R, Mahalingam D, O/’Dwyer M, et al. Cdc7 kinase – a new target for drug development. Eur J Cancer. 2010 Jan;46(1):33-40. doi: 10.1016/j.ejca.2009.09.020. 


[3]. Montagnoli A, Moll J, Colotta F. Targeting cell division cycle 7 kinase: a new approach for cancer therapy. Clin Cancer Res. 2010 Sep 15;16(18):4503-8. doi: 10.1158/1078-0432.CCR-10-0185. Epub 2010 Jul 20. 


[4]. Montagnoli A, Valsasina B, Croci V, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65. doi: 10.1038/nchembio.90.