PHA-767491 hydrochloride

For research use only, not for therapeutic use.

  • CAT Number: I005601
  • CAS Number: 942425-68-5
  • Molecular Formula: C12H11N3O.HCl
  • Molecular Weight: 249.70
  • Purity: ≥95%
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PHA-767491 hydrochloride(Cat No.:I005601)is a selective inhibitor of the protein kinase GSK-3 (glycogen synthase kinase 3), which is involved in numerous cellular processes, including glycogen metabolism, cell differentiation, and the regulation of signaling pathways related to cancer and neurodegenerative diseases. By inhibiting GSK-3, PHA-767491 hydrochloride can enhance Wnt signaling and promote neuroprotection, making it a candidate for therapeutic applications in conditions such as Alzheimer’s disease and various cancers. Ongoing research is focused on its pharmacological properties, safety profile, and potential clinical uses to leverage its beneficial effects in targeted therapies.


Catalog Number I005601
CAS Number 942425-68-5
Synonyms

PHA767491 hydrochloride; PHA-767491 hcl

Molecular Formula C12H11N3O.HCl
Purity ≥95%
Target Cdc7/CDK9
Solubility DMSO: < 9 mg/mL
Storage 3 years -20C powder
IC50 10 nM(Cdc7); 34 nM(Cdk9) Target: Cdc7/CDK9
IUPAC Name 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one;hydrochloride
InChI InChI=1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H
InChIKey IMVNFURYBZMFDZ-UHFFFAOYSA-N
SMILES C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3.Cl
Reference

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[1]. Natoni, Alessandro; Murillo, Laura S.; Kliszczak, Anna E. et al. Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells. Molecular Cancer Therapeutics (2011), 10(9), 1624-1634.&nbsp;
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[2]. Swords R, Mahalingam D, O/’Dwyer M, et al. Cdc7 kinase – a new target for drug development. Eur J Cancer. 2010 Jan;46(1):33-40. doi: 10.1016/j.ejca.2009.09.020.&nbsp;
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[3]. Montagnoli A, Moll J, Colotta F. Targeting cell division cycle 7 kinase: a new approach for cancer therapy. Clin Cancer Res. 2010 Sep 15;16(18):4503-8. doi: 10.1158/1078-0432.CCR-10-0185. Epub 2010 Jul 20.&nbsp;
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[4]. Montagnoli A, Valsasina B, Croci V, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65. doi: 10.1038/nchembio.90.
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