PHD-1-IN-1

• CAT Number: I015461
• CAS Number: 2009343-14-8
• Molecular Formula: C13H8N4
• Molecular Weight: 220.23
• Purity: ≥95%
• Synonyms: 4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile
• InChI: InChI=1S/C13H8N4/c14-8-10-4-6-11(7-5-10)12-2-1-3-13-15-9-16-17(12)13/h1-7,9H
• InChIKey: DEYMFBHALUHGST-UHFFFAOYSA-N
• SMILES: C1=CC2=NC=NN2C(=C1)C3=CC=C(C=C3)C#N

PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an “Arg367-out” pocket[1].
PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng•h/mL, Kp,uu of 1.11 and B/P of 0.95[1].

Reference

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jul 13;60(13):5663-5672.
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