Phe-Lys(Fmoc)-PAB

• CAT Number: I017592
• CAS Number: 2149584-03-0
• Molecular Formula: C₃₇H₄₀N₄O₅
• Molecular Weight: 620.74
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: 9H-fluoren-9-ylmethyl N-[(5S)-5-[[(2S)-2-amino-3-phenylpropanoyl]amino]-6-[4-(hydroxymethyl)anilino]-6-oxohexyl]carbamate
• InChI: InChI=1S/C37H40N4O5/c38-33(22-25-10-2-1-3-11-25)35(43)41-34(36(44)40-27-19-17-26(23-42)18-20-27)16-8-9-21-39-37(45)46-24-32-30-14-6-4-12-28(30)29-13-5-7-15-31(29)32/h1-7,10-15,17-20,32-34,42H,8-9,16,21-24,38H2,(H,39,45)(H,40,44)(H,41,43)/t33-,34-/m0/s1
• InChIKey: RCPHMUPZDFKBDS-HEVIKAOCSA-N
• SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)NC5=CC=C(C=C5)CO)N

Phe-Lys(Fmoc)-PAB(CAT: I017592) is a specialized peptide-based compound used in the synthesis of advanced drug delivery systems and prodrugs. Featuring a phenylalanine (Phe) residue, an N-terminal Fmoc-protected lysine (Lys), and a para-aminobenzyl (PAB) spacer, this compound is designed for targeted applications in bioconjugation and linker chemistry. The PAB moiety acts as a self-immolative linker, facilitating controlled release of active pharmaceutical ingredients in response to specific stimuli. Phe-Lys(Fmoc)-PAB is widely employed in the development of antibody-drug conjugates (ADCs) and other precision therapeutics, offering researchers a versatile and reliable tool for exploring innovative drug delivery mechanisms in cancer and biomedical research.