Phenadoxone

• CAT Number: I034569
• CAS Number: 467-84-5
• Molecular Formula: C23H29NO2
• Molecular Weight: 351.49
• Purity: 98%
• Synonyms: Phenadoxone; CB11; CB-11; CB 11
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-Heptanone, 4,4-diphenyl-6-morpholino-
• InChI: InChI=1S/C23H29NO2/c1-3-22(25)23(20-10-6-4-7-11-20,21-12-8-5-9-13-21)18-19(2)24-14-16-26-17-15-24/h4-13,19H,3,14-18H2,1-2H3
• InChIKey: LOXCOAXRHYDLOW-UHFFFAOYSA-N
• SMILES: CCC(C(C1=CC=CC=C1)(C2=CC=CC=C2)CC(N3CCOCC3)C)=O

Phenadoxone is an opioid analgesic of the open chain class invented in Germany by Hoechst in 1947.

Reference

1: SHAW WH, JEFFERIES JP. The determination of phenadoxone. J Pharm Pharmacol. 1951 Nov;3(11):823-8. doi: 10.1111/j.2042-7158.1951.tb13126.x. PMID: 14898462.
2: BASIL B, EDGE ND, SOMERS GF. The pharmacology of phenadoxone or dl-6-morpholino-4:4-diphenyl-heptan-3-one hydrochloride. Br J Pharmacol Chemother. 1950 Mar;5(1):125-41. doi: 10.1111/j.1476-5381.1950.tb00582.x. PMID: 15405474; PMCID: PMC1509948.
3: VENTURI VM. Farmacologia del fenadoxone [Pharmacology of phenadoxone]. Farmaco Sci Tec. 1950 Mar-Apr;5(2):185-6. Undetermined Language. PMID: 15421358.
4: Robinson K, Smith RN. Methadone radioimmunoassay: two simple methods. J Pharm Pharmacol. 1983 Sep;35(9):566-70. doi: 10.1111/j.2042-7158.1983.tb04334.x. PMID: 6138405.
5: GREEN AF. Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion. Br J Pharmacol Chemother. 1959 Mar;14(1):26-34. doi: 10.1111/j.1476-5381.1959.tb00924.x. PMID: 13651575; PMCID: PMC1481834.
6: Paton WD. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. 1956. Br J Pharmacol. 1997 Feb;120(4 Suppl):123-31; discussion 121-2. doi: 10.1111/j.1476-5381.1997.tb06787.x. PMID: 9142400; PMCID: PMC3224282.
7: PATON WD. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br J Pharmacol Chemother. 1957 Mar;12(1):119-27. doi: 10.1111/j.1476-5381.1957.tb01373.x. PMID: 13413163; PMCID: PMC1509640.