For research use only. Not for therapeutic Use.
Phenethyl Isothiocyanate (Cat No.:R004533) is a naturally occurring compound found in cruciferous vegetables like broccoli and watercress. It has gained attention for its potential anticancer, antimicrobial, and anti-inflammatory properties. PEITC is known to induce apoptosis in cancer cells, inhibit tumor growth, and activate antioxidant pathways. Its bioactivity is attributed to its ability to modulate enzymes involved in detoxification and cell signaling. Used in various research applications, Phenethyl Isothiocyanate is a valuable tool in studies exploring natural chemopreventive agents and their impact on human health.
| Catalog Number | R004533 |
| CAS Number | 2257-09-2 |
| Synonyms | 2-Phenylethyl Isothiocyanate; (2-Isothiocyanatoethyl)benzene; Phenethyl Mustard Oil; |
| Molecular Formula | C9H9NS |
| Purity | ≥95% |
| Target | Fungal |
| Storage | -20°C |
| IUPAC Name | 2-isothiocyanatoethylbenzene |
| InChI | InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2 |
| InChIKey | IZJDOKYDEWTZSO-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CCN=C=S |
| Reference | </br>1:Fatty Acid Synthesis Intermediates Represent Novel Noninvasive Biomarkers of Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate. Singh KB, Singh SV.Cancer Prev Res (Phila). 2017 May;10(5):279-289. doi: 10.1158/1940-6207.CAPR-17-0001. Epub 2017 Mar 14. PMID: 28292742 </br>2:Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway. Shao WY, Yang YL, Yan H, Huang Q, Liu KJ, Zhang S.Cancer Biol Ther. 2017 Jan 2;18(1):26-35. doi: 10.1080/15384047.2016.1264540. Epub 2016 Dec 16. PMID: 27981892 </br>3:Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells. Boyanapalli SS, Li W, Fuentes F, Guo Y, Ramirez CN, Gonzalez XP, Pung D, Kong AN.Pharmacol Res. 2016 Dec;114:175-184. doi: 10.1016/j.phrs.2016.10.021. Epub 2016 Nov 3. PMID: 27818231 </br>4:Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical. Kumari V, Dyba MA, Holland RJ, Liang YH, Singh SV, Ji X.PLoS One. 2016 Sep 29;11(9):e0163821. doi: 10.1371/journal.pone.0163821. eCollection 2016. PMID: 27684484 Free PMC Article</br>5:Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells. Kasukabe T, Honma Y, Okabe-Kado J, Higuchi Y, Kato N, Kumakura S.Oncol Rep. 2016 Aug;36(2):968-76. doi: 10.3892/or.2016.4867. Epub 2016 Jun 10. PMID: 27375275 </br>6:MiR-135a and MRP1 play pivotal roles in the selective lethality of phenethyl isothiocyanate to malignant glioma cells. Zhang T, Shao Y, Chu TY, Huang HS, Liou YL, Li Q, Zhou H.Am J Cancer Res. 2016 May 1;6(5):957-72. eCollection 2016. PMID: 27293991 Free PMC Article</br>7:Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Aggarwal M, Saxena R, Sinclair E, Fu Y, Jacobs A, Dyba M, Wang X, Cruz I, Berry D, Kallakury B, Mueller SC, Agostino SD, Blandino G, Avantaggiati ML, Chung FL.Cell Death Differ. 2016 Oct;23(10):1615-27. doi: 10.1038/cdd.2016.48. Epub 2016 Jun 3. PMID: 27258787 Free PMC Article</br>8:Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats. Kim JK, Gallaher DD, Chen C, Gallaher CM, Yao D, Trudo SP.Mol Nutr Food Res. 2016 Sep;60(9):1956-66. doi: 10.1002/mnfr.201500790. Epub 2016 Jun 6. PMID: 27133590 </br>9:2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke. Yuan JM, Murphy SE, Stepanov I, Wang R, Carmella SG, Nelson HH, Hatsukami D, Hecht SS.Cancer Prev Res (Phila). 2016 Jul;9(7):598-606. doi: 10.1158/1940-6207.CAPR-16-0032. Epub 2016 Apr 20. PMID: 27099270 </br>10:Establishment of prostate cancer spheres from a prostate cancer cell line after phenethyl isothiocyanate treatment and discovery of androgen-dependent reversible differentiation between sphere and neuroendocrine cells. Chen Y, Cang S, Han L, Liu C, Yang P, Solangi Z, Lu Q, Liu D, Chiao JW.Oncotarget. 2016 May 3;7(18):26567-79. doi: 10.18632/oncotarget.8440. PMID: 27034170 Free PMC Article |
