For research use only. Not for therapeutic Use.
Phenindamine tartrate (Cat No.: I008745) is a first-generation antihistamine that acts as an H₁ receptor antagonist, used to relieve allergy symptoms such as hay fever, urticaria, and rhinitis. It has additional anticholinergic and mild sedative properties, making it effective in treating motion sickness and mild insomnia. Unlike some older antihistamines, Phenindamine exhibits less drowsiness while still providing effective allergy relief. It has been studied for its potential in cold medications and antihistamine therapy, offering symptomatic relief in various allergic and respiratory conditions.
| CAS Number | 569-59-5 |
| Synonyms | Phenindamine Tartrate; Pernovine, Plegine, Phenindamine, Nolahist; Thephorin; Phenindamine tartrate; Mixture Name, PV Tussin Syrup, PV Tussin Tablet, Nolahist (TN), Phenindamine bitartrate; Phenindamine hydrogen tartrate; Phenindamine tartrate (USAN) |
| Molecular Formula | C23H25NO6 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 2,3-dihydroxybutanedioic acid;2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine |
| InChI | 1S/C19H19N.C4H6O6/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14;5-1(3(7)8)2(6)4(9)10/h2-10,19H,11-13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10) |
| InChIKey | WFXURHIXPXVPGM-UHFFFAOYSA-N |
| SMILES | CN1CCC2=C(C1)C(C3=CC=CC=C23)C4=CC=CC=C4.C(C(C(=O)O)O)(C(=O)O)O |
| Reference | </br>1:The effects of phenindamine tartrate on sleepiness and psychomotor performance. Witek TJ Jr, Canestrari DA, Miller RD, Yang JY, Riker DK.J Allergy Clin Immunol. 1992 Dec;90(6 Pt 1):953-61. PMID: 1360991 </br>2:Determination of isophenindamine in phenindamine tartrate using an argentated high-performance liquid chromatographic mobile phase. Tscherne RJ, Umagat H.J Pharm Sci. 1980 Mar;69(3):342-4. PMID: 7381716 </br>3:Bladder dysfunction following ingestion of phenindamine tartrate (thephorin). UHLE CA, KNOCH HR.J Am Med Assoc. 1951 Aug 4;146(14):1319-20. No abstract available. PMID: 14850285 |
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