Phenoxybenzamine-d5 Hydrochloride

• CAT Number: R048393
• CAS Number: 1329838-45-0
• Molecular Formula: C18H23Cl2NO
• Molecular Weight: 345.319
• Purity: ≥95%
• Synonyms: N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine-d5 Hydrochloride; N-2-Phenoxyisopropyl-N-benzyl-β-chloroethylamine-d5 Hydrochloride; Dibenzyline-d5 Chloride; Dibenzyline-d5 Hydrochloride; Dibenzyran-d5; NSC 37448-d5
• Target: Neuronal Signaling
• Storage: -20°C
• IUPAC Name: N-benzyl-N-(2-chloroethyl)-1-(2,3,4,5,6-pentadeuteriophenoxy)propan-2-amine;hydrochloride
• InChI: InChI=1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H/i3D,6D,7D,10D,11D
• InChIKey: VBCPVIWPDJVHAN-PEEBBJRGSA-N
• SMILES: CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl

Phenoxybenzamine-d5 Hydrochloride is a deuterated form of phenoxybenzamine, a non-selective alpha-adrenergic antagonist used to manage conditions like high blood pressure and excessive sweating, particularly in patients with pheochromocytoma. In this version, five hydrogen atoms are replaced with deuterium, enhancing its utility in pharmacokinetic and metabolic studies. The deuterium labeling allows for precise tracking and differentiation in mass spectrometry and NMR spectroscopy. The hydrochloride salt form improves solubility and stability. Despite the isotopic substitution, Phenoxybenzamine-d5 retains the same pharmacological properties as the non-deuterated form, making it valuable for research purposes.