For research use only. Not for therapeutic Use.
Phensuximide is an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
| Catalog Number | R061507 |
| CAS Number | 86-34-0 |
| Synonyms | N-Methyl-2-phenyl-succinimide; (±)-Phensuximide; 1-Methyl-3-phenyl-2,5-pyrrolidinedione; 1-Methyl-3-phenylsuccinimide; Epimid; Lifene; Milontin; Milonton; Mirontin; N-Methyl-2-phenylsuccinimide; N-Methyl-3-phenylpyrrolidinedione; N-Methyl-3-phenylsuc |
| Molecular Formula | C11H11NO2 |
| Purity | ≥95% |
| Storage | 3 years -20C powder |
| IUPAC Name | 1-methyl-3-phenylpyrrolidine-2,5-dione |
| InChI | InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3 |
| InChIKey | WLWFNJKHKGIJNW-UHFFFAOYSA-N |
| SMILES | CN1C(=O)CC(C1=O)C2=CC=CC=C2 |
| Reference | </br>1:Role of para-hydroxylation in phensuximide-induced urotoxicity in the Fischer 344 rat. Rankin GO, Beers KW, Nicoll DW, Anestis DK, Shih HC, Brown PI, Hubbard JL.Toxicology. 1992 Aug;74(1):77-88. PMID: 1514190 </br>2:Acute effects of the antiepileptic succinimides on the urinary tract and potentiation of phensuximide-induced urotoxicity by phenobarbital. Rankin GO, Teets VJ, Nicoll DW, Brown PI.J Appl Toxicol. 1990 Jun;10(3):203-9. PMID: 2380483 </br>3:Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. Rankin GO, Cressey-Veneziano K, Wang RT, Brown PI.J Appl Toxicol. 1986 Oct;6(5):349-56. PMID: 3772011 </br>4:Synthesis and anticancer activity of nitrosourea derivatives of phensuximide. Crider AM, Kolczynski TM, Yates KM.J Med Chem. 1980 Mar;23(3):324-6. PMID: 7365750 </br>5:Plasma concentrations of phensuximide, methsuximide, and their metabolites in relation to clinical efficacy. Porter RJ, Penry JK, Lacy JR, Newmark ME, Kupferberg HJ.Neurology. 1979 Nov;29(11):1509-13. PMID: 116142 </br>6:Pro-drugs as drug delivery systems. V. Cyclization of methyl esters of succinamic and glutaramic acids to the corresponding imides (phensuximide and glutethimide) in aqueous solution. Bundgaard H, Larsen C.Acta Pharm Suec. 1979;16(5):309-18. No abstract available. PMID: 44070 </br>7:[On the polymorphism of drugs: medrogestone, phensuximide and protionamide (author/’s transl)]. Kuhnert-Brandstätter M, Bösch L.Arch Pharm (Weinheim). 1978 Sep;311(9):757-61. German. No abstract available. PMID: 708206 </br>8:Comparison of the therapeutic effects of trimethadione and phensuximide in acute organophosphate intoxications. Grudzinska E, Lechowska-Postek M, Ilczuk I, Rump S.Ther Hung. 1978;26(3):119-23. No abstract available. PMID: 364759 </br>9:[Drug information. Therapeutic main group: anti-epileptics – anticonvulsants. Succinimides (ethosuximide and phensuximide), oxazolidines (trimethadione and paramethadione), sulfonamide groups (acetazolamide and sulthiame)]. Lumholtz IB.Sygeplejersken. 1977 Feb 23;77(8):11. Danish. No abstract available. PMID: 584547 </br>10:NMR analysis of pharmaceuticals. X. Determination of methsuximide and phensuximide in capsules. Turczan JW, Goldwitz BA.J Pharm Sci. 1973 Oct;62(10):1705-7. No abstract available. PMID: 4752119 |
