Phentolamine

• CAT Number: I034633
• CAS Number: 50-60-2
• Molecular Formula: C17H19N3O
• Molecular Weight: 281.36
• Purity: 98%
• Synonyms: Phentolamine; C 7337; C 7337 Ciba; HSDB 3382
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol
• InChI: InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
• InChIKey: MRBDMNSDAVCSSF-UHFFFAOYSA-N
• SMILES: OC1=CC=CC(N(CC2=NCCN2)C3=CC=C(C)C=C3)=C1

Phentolamine(CAT: I034633) is a non-selective α-adrenergic receptor antagonist that blocks both α1 and α2 adrenergic receptors. By inhibiting these receptors, phentolamine causes vasodilation, leading to decreased vascular resistance and blood pressure. It is primarily used to manage and prevent hypertensive crises, particularly in patients with pheochromocytoma, a tumor of the adrenal gland that causes excessive catecholamine release. Additionally, phentolamine is used to reverse soft tissue anesthesia and to treat erectile dysfunction when administered intracavernosally. Its ability to modulate vascular tone makes it valuable in cardiovascular research and hypertension management.