(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate

• CAT Number: I040100
• Molecular Formula: C54H76N14O11.xC2H4O2
• Molecular Weight: 1097.27 (free base)
• Purity: ≥95%

(Phenylac¹,D-Tyr(Et)²,Lys⁶,Arg⁸,des-Gly⁹)-Vasopressin acetate (Cat No.: I040100) is a synthetic analog of vasopressin modified to enhance receptor selectivity and metabolic stability. It features substitutions such as phenylacetyl at position 1, ethylated D-tyrosine at position 2, and omission of glycine at position 9. These modifications aim to improve potency and duration of action, particularly at vasopressin V1 or V2 receptors. This peptide is primarily used in biochemical and pharmacological research to study vasopressin receptor activity, water homeostasis, and cardiovascular or renal regulation mechanisms.

Reference

[1]. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats[1].
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