Phenylbutazone

• CAT Number: A000932
• CAS Number: 50-33-9
• Molecular Formula: C19H20N2O2
• Molecular Weight: 308.4
• Purity: ≥95%
• Synonyms: 50-33-9; Fenilbutazona; Butazolidin; Diphenylbutazone; 4-Butyl-1,2-diphenylpyrazolidine-3,5-dione
• Target: COX
• Storage: -20°C
• InChI: 1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
• InChIKey: VYMDGNCVAMGZFE-UHFFFAOYSA-N
• SMILES: CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Phenylbutazone acts as a potentent anti-inflammatory agent and mediates prostaglandin synthesis. It also is useful in rheumatoid arthritis and Reiter/’s syndrome (investigational indication). Phenylbutazone may be of interest regarding research into anti-proliferative effects as well. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.

Reference

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