Phenylbutazone calcium

For research use only. Not for therapeutic Use.

  • CAT Number: I034640
  • CAS Number: 70145-60-7
  • Molecular Formula: C38H38CaN4O4
  • Molecular Weight: 654.824
  • Purity: 98%
Inquiry Now

Phenylbutazone calcium (Cat.No:I034640) is a calcium salt form of phenylbutazone, a nonsteroidal anti-inflammatory drug (NSAID). It is commonly used in veterinary medicine to alleviate pain and inflammation in horses. Phenylbutazone calcium acts by inhibiting the synthesis of prostaglandins, thereby providing relief from conditions such as arthritis and musculoskeletal injuries in equine patients.


Catalog Number I034640
CAS Number 70145-60-7
Synonyms

Phenylbutazone calcium; DA-241; DA241; DA 241; P 241; Phenylbutazone calcium salt;

Molecular Formula C38H38CaN4O4
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name calcium 4-butyl-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrazol-3-olate
InChI InChI=1S/2C19H20N2O2.Ca/c2*1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16;/h2*4-13,22H,2-3,14H2,1H3;/q;;+2/p-2
InChIKey XMVFRSAMWBGRNR-UHFFFAOYSA-L
SMILES [O-]C1=C(CCCC)C(N(C2=CC=CC=C2)N1C3=CC=CC=C3)=O.[O-]C4=C(CCCC)C(N(C5=CC=CC=C5)N4C6=CC=CC=C6)=O.[Ca+2]
Reference

1: Hanada S, Mengardo S, Oga S. Bioavailability and anti-inflammatory effects of phenylbutazone sodium and phenylbutazone calcium in rats. Boll Chim Farm. 1987 May;126(5):203-7. PubMed PMID: 3450309.
2: Neuschl J, Kohút A. [Effect of amitriptyline on the ulcerogenic action of phenylbutazone and reserpine with respect to calcium levels in the stomach wall and blood in rats of different ages (author’s transl)]. Bratisl Lek Listy. 1979 Feb;71(2):173-8. Slovak. PubMed PMID: 427612.
3: Carlassare M. [Calcium phenylbutazone]. Boll Chim Farm. 1971 Sep;110(9):510-4. Italian. PubMed PMID: 5137988.
4: BAUST W, KRAATZ HG. [A calcium-like effect of phenylbutazone (butazolidin)]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1958;232(3):562-72. German. PubMed PMID: 13552733.
5: RATTI G. [Calcium derivative of phenylbutazone]. Reumatismo. 1957;9(Suppl 1):95-7. Italian. PubMed PMID: 13441980.
6: Neuschl J, Kohút A, Nicák A. [The effect of calcium chloride on the ulcerogenic effects of phenylbutazone and reserpine in relation to the calcium content of the stomach wall in rats of various ages]. Cesk Gastroenterol Vyz. 1983 Mar;37(2):98-102. Slovak. PubMed PMID: 6850876.
7: Spilberg I, Gallacher A, Mandell B, Rosenberg D. A mechanism of action for non-steroidal anti-inflammatory agents in calcium pyrophosphate dihydrate (CPPD) crystal induced arthritis. Agents Actions. 1977 Mar;7(1):153-5. PubMed PMID: 193386.
8: SPILDBORGHS G, NEBO F. [Evaluation of the use of the calcium salt of phenylbutazone in rheumatoid arthritis in adults]. Rev Bras Med. 1957 Dec;14(12):859-61. Portuguese. PubMed PMID: 13568199.
9: MARINI A, PICENI-SERENI L. [Use of phenylbutazone calcium salt (P 241) in the treatment of rheumatic fever in childhood]. Arcisp S Anna Ferrara. 1956;9(3):461-90. Italian. PubMed PMID: 13355641.
10: Neuschl J, Kohút A, Nicák A. [Influence of nialamide on the ulcerogenic action of phenylbutazone and reserpine in relation to calcium levels in the gastric wall and blood of rats of different age (author’s transl)]. Cesk Gastroenterol Vyz. 1979 Jun;33(4):191-5. Slovak. PubMed PMID: 509570.
11: STENGER EG. [Antiphlogistic effect of phenylbutazone in calcium cyanide-, monoiodo-acetic acid- and sodium fluoride-induced edema of rat paw]. Arzneimittelforschung. 1958 Sep;8(9):622. German. PubMed PMID: 13607284.
12: Lin K, Sadée W, Quillan JM. Rapid measurements of intracellular calcium using a fluorescence plate reader. Biotechniques. 1999 Feb;26(2):318-22, 324-6. PubMed PMID: 10023544.
13: Hansson L, Huunan-Seppälä A, Mattila A. The content of calcium, magnesium, copper, zinc, lead and chromium in the blood of patients with rheumatoid arthritis. Scand J Rheumatol. 1975;4(1):33-8. PubMed PMID: 1153978.
14: Parkinson N, Bolsover S, Mason W. Nuclear and cytosolic calcium changes in osteoclasts stimulated with ATP and integrin-binding peptide. Cell Calcium. 1998 Sep;24(3):213-21. PubMed PMID: 9883275.
15: Neuschl J. [Relation of nonsteroidal anti-inflammatory agents and reserpine to calcium homeostasis]. Cesk Farm. 1987 Sep;36(7):312-6. Slovak. PubMed PMID: 3664648.
16: Denko CW, Whitehouse MW. Experimental inflammation induced by naturally occurring microcrystalline calcium salts. J Rheumatol. 1976 Mar;3(1):54-62. PubMed PMID: 1271389.
17: Spahn H, Mutschler E, Geissler HE, Faust-Tinnefeldt G. [Comparison of bumadizone-, phenylbutazone- and oxyphenbutazone-plasma levels after a single oral dose of phenylbutazone and of bumadizone, respectively (author’s transl)]. Arzneimittelforschung. 1981;31(3):499-503. German. PubMed PMID: 6894380.
18: Breull W, Karzel K. Influence of phenylbutazone on the membrane resting potential of frog skeletal muscle fibres in vitro. Pharmacology. 1970;4(1):25-32. PubMed PMID: 5431770.
19: Neuschl J, Kohút A, Nicák A. [The relationship between the levels of calcium on the stomach wall and in the blood and ulcerogenic effect of phenylbutazone and reserpine in intact, adrenalectomized and vagotomized rats of various age (author’s transl)]. Cesk Gastroenterol Vyz. 1978 Mar;32(2):85-90. Slovak. PubMed PMID: 657308.
20: Snow DH, Bogan JA, Douglas TA, Thompson H. Phenylbutazone toxicity in ponies. Vet Rec. 1979 Jul 14;105(2):26-30. PubMed PMID: 555115.

Request a Quote