For research use only. Not for therapeutic Use.
PHGDH-inactive has no activity against PHGDH and serves as a negative control of NCT-502 and NCT-503[1].
PHGDH-inactive has no activity against PHGDH and serves as a negative control[1].
| Catalog Number | I011572 |
| CAS Number | 1914971-16-6 |
| Synonyms | N-(4,6-dimethylpyridin-2-yl)-4-pyridin-4-ylpiperazine-1-carbothioamide |
| Molecular Formula | C17H21N5S |
| Purity | ≥95% |
| InChI | InChI=1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23) |
| InChIKey | ITLPIAAGIQAGRA-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)C3=CC=NC=C3)C |
| Reference | [1]. Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [published correction appears in Nat Chem Biol. 2016 Jul 19;12 (8):656]. Nat Chem Biol. 2016;12(6):452-458. |
