Phleomycin

• CAT Number: M064535
• CAS Number: 11006-33-0
• Molecular Formula: C51H75N17O21S2
• Molecular Weight: 1326.38
• Purity: ≥95%
• Synonyms: (2R,3S,4S,5R,6R)-2-(((2R,3S,4S,5S,6S)-2-(2-(6-amino-2-(3-amino-1-((2,3-diamino-3-oxopropyl)amino)-3-oxopropyl)-5-methylpyrimidine-4-carboxamido)-3-((5-((1-((2-(4-((4-guanidinobutyl)carbamoyl)-4/’,5/’-dihydro-[2,4/’-bithiazol]-2/’-yl)ethyl)amino)-3-hy
• Target: Cell Cycle/DNA Damage
• Storage: Store at -20°C
• IUPAC Name: 2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[3-[4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)-3-methyloxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-oxobutanoyl]amino]ethyl]-4,5-dihydro-1,3-thiazol-4-yl]-1,3-thiazole-4-carboxamide
• InChI: InChI=1S/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)
• InChIKey: QRBLKGHRWFGINE-UHFFFAOYSA-N
• SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)(C)OC4C(C(C(C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O

Phleomycin（Cat No.:M064535）is a glycopeptide antibiotic in the bleomycin family, derived from Streptomyces verticillus. It is primarily used in research for its ability to induce DNA breaks, inhibiting DNA synthesis and repair, which leads to cell death. This property makes phleomycin effective against a wide range of organisms, including bacteria, fungi, and even mammalian cells, often serving as a selective agent in genetic studies and molecular biology applications. Phleomycin is also valuable in creating stable cell lines carrying specific genes, as only resistant cells survive its cytotoxic effects.