For research use only. Not for therapeutic Use.
Very potent and selective D2 agonist, more active enantiomer. Note: Appropriate chiral precursor(s) for making D2 radiotracer, [11C]-(+)-PHNO, can be provided on request.
KEYWORDS: (+)-PHNO hydrochloride | supplier | D2 agonist | Naxagolide | Dopazinol | PHNO |CAS[99705-65-4] | [88058-88-2] | Dopamine | D2 | Agonist | radiotracer | enantiomer
| Catalog Number | R008545 |
| CAS Number | 99705-65-4 |
| Molecular Formula | C15H21NO2.HCl |
| Purity | ≥95% |
| IUPAC Name | (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol;hydrochloride |
| InChI | InChI=1S/C15H21NO2.ClH/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16;/h3,5,10,14-15,17H,2,4,6-9H2,1H3;1H/t14-,15-;/m1./s1 |
| SMILES | CCCN1CCO[C@H]2[C@H]1CCC3=C2C=C(C=C3)O.Cl |
| Reference | Martin et al. Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo. J. Pharmacol. Exp. Ther. 1985, 233, 2, 395-401.
N Ginovart et al. Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography. J. Neurochem. 2006, 97, 1089-1103
P Seeman et al. Dopamine receptors labelled by PHNO. Synapse. 1993, 14(4), 254-62.
A Graff-Guerrero et al. The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO. Arch Gen Psychiatry. 2009, 66(6), 606-15. |
