For research use only. Not for therapeutic Use.
Phorbol is a toxic diterpene compound extracted from the seeds of Euphorbiaceae plants. It has high biological activity and has many pharmacological effects such as promoting tumor, inflammation and immune regulation. It activates protein kinase C ( PKC ), a key enzyme in cell signal transduction and regulation, and its toxicity is attributed to its ability to interfere with normal cellular processes.
| Catalog Number | I002298 |
| CAS Number | 17673-25-5 |
| Molecular Formula | C20H28O6 |
| Purity | ≥95% |
| Solubility | H<sub>2</sub>O |
| Storage | Store at -20°C |
| IUPAC Name | (1S,2S,6R,10S,11R,13S,14R,15R)-1,6,13,14-tetrahydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dien-5-one |
| InChI | InChI=1S/C20H28O6/c1-9-5-13-18(24,15(9)22)7-11(8-21)6-12-14-17(3,4)20(14,26)16(23)10(2)19(12,13)25/h5-6,10,12-14,16,21,23-26H,7-8H2,1-4H3/t10-,12+,13-,14-,16-,18-,19-,20-/m1/s1 |
| InChIKey | QGVLYPPODPLXMB-UBTYZVCOSA-N |
| SMILES | CC1C(C2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)O)O |
| Reference | <p style=/line-height:25px/> <br>[2]. Hikima T, et al. beta-Phorbol ester-induced enhancement of exocytosis in large mossy fiber boutons of mouse hippocampus. J Physiol Sci. 2009 Jul;59(4):263-74. <br>[3]. guyen T, et al. Delta protein kinase C interacts with the d subunit of the F1F0 ATPase in neonatal cardiac myocytes exposed to hypoxia or phorbol ester. Implications for F1F0 ATPase regulation. J Biol Chem. 2008 Oct 31;283(44):29831-40. <br>[4]. Schomerus C, et al. Activation of arylalkylamine N-acetyltransferase by phorbol esters in bovine pinealocytes suggests a novel regulatory pathway in melatonin synthesis. J Neuroendocrinol. 2004 Sep;16(9):741-9. <br>[5]. Cox A, et al. Inhibition of cromolyn-induced phosphorylation of a 78-kDa protein by phorbol esters in rat peritoneal mast cells. Biochem Pharmacol. 1998 Mar 1;55(5):585-94. </p> |
