Phosmet oxon

For research use only. Not for therapeutic Use.

  • CAT Number: I034659
  • CAS Number: 3735-33-9
  • Molecular Formula: C11H12NO5PS
  • Molecular Weight: 301.25
  • Purity: 98%
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Phosmet oxon (Cat No.:I034659) is a toxic metabolite derived from the pesticide phosmet. Primarily used as an insecticide in agriculture, it acts as an acetylcholinesterase inhibitor, disrupting the nervous system of insects. However, phosmet oxon poses significant health risks to humans and animals. It is highly toxic, potentially causing neurotoxicity and respiratory effects. Due to its hazardous nature, strict safety measures and regulations are necessary to mitigate exposure.


Catalog Number I034659
CAS Number 3735-33-9
Synonyms

Phosmet oxon; R 1571; R-1571; R1571; ENT 25707; ENT-25707; ENT25707

Molecular Formula C11H12NO5PS
Purity 98%
Target Drug Metabolite
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name S-((1,3-dioxoisoindolin-2-yl)methyl) O,O-dimethyl phosphorothioate
InChI InChI=1S/C11H12NO5PS/c1-16-18(15,17-2)19-7-12-10(13)8-5-3-4-6-9(8)11(12)14/h3-6H,7H2,1-2H3
InChIKey BEMXOWRVWRNPPL-UHFFFAOYSA-N
SMILES O=P(OC)(SCN1C(C2=CC=CC=C2C1=O)=O)OC
Reference

1: Lucini L, Molinari GP. Performance and matrix effect observed in QuEChERS extraction and tandem mass spectrometry analyses of pesticide residues in different target crops. J Chromatogr Sci. 2011 Oct;49(9):709-14. doi: 10.1093/chrsci/49.9.709. PubMed PMID: 22586248.
2: Salles NA, Fourcade F, Geneste F, Floner D, Amrane A. Relevance of an electrochemical process prior to a biological treatment for the removal of an organophosphorous pesticide, phosmet. J Hazard Mater. 2010 Sep 15;181(1-3):617-23. doi: 10.1016/j.jhazmat.2010.05.057. Epub 2010 May 21. PubMed PMID: 20538412.
3: Hernández F, Grimalt S, Pozo OJ, Sancho JV. Use of ultra-high-pressure liquid chromatography-quadrupole time-of-flight MS to discover the presence of pesticide metabolites in food samples. J Sep Sci. 2009 Jul;32(13):2245-61. doi: 10.1002/jssc.200900093. PubMed PMID: 19569104.
4: Kamel A, Byrne C, Vigo C, Ferrario J, Stafford C, Verdin G, Siegelman F, Knizner S, Hetrick J. Oxidation of selected organophosphate pesticides during chlorination of simulated drinking water. Water Res. 2009 Feb;43(2):522-34. doi: 10.1016/j.watres.2008.10.038. Epub 2008 Oct 29. PubMed PMID: 19027135.
5: Cunha SC, Fernandes JO, Beatriz M, Oliveira PP. Determination of phosmet and its metabolites in olives by matrix solid-phase dispersion and gas chromatography-mass spectrometry. Talanta. 2007 Sep 30;73(3):514-22. doi: 10.1016/j.talanta.2007.04.014. Epub 2007 Apr 24. PubMed PMID: 19073064.
6: Crowe KM, Bushway AA, Bushway RJ, Hazen RA. Evaluation of chemical and photochemical oxidation processes for degradation of phosmet on lowbush blueberries (Vaccinium angustifolium). J Agric Food Chem. 2006 Dec 13;54(25):9608-13. PubMed PMID: 17147453.
7: Sinderhauf K, Schwack W. Photodegradation chemistry of the insecticide phosmet in lipid models and in the presence of wool wax, employing a 15N-labeled compound. J Agric Food Chem. 2004 Dec 29;52(26):8046-52. PubMed PMID: 15612794.
8: de Potás GM, de D’Angelo AM. Phosphoinositide phosphorylation and shape changes produced by phosmet-oxon in human erythrocytes. Comp Biochem Physiol C. 1993 Oct;106(2):561-6. PubMed PMID: 7904927.

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