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51446-62-9-Phosphatidylserine Phosphatidylserine

Phosphatidylserine

For research use only. Not for therapeutic Use.

  • CAT Number: I008752
  • CAS Number: 51446-62-9
  • Molecular Formula: C42H82NO10P
  • Molecular Weight: 792.089
  • Purity: ≥95%
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Related Small Molecules: Dihydrolapachenole     Kartogenin     PSI-7409 tetrasodium    

Phosphatidylserine(CAT: I008752) is a phospholipid that is present in cell membranes in the body. Phosphatidylserine plays an important role in the structure and function of cell membranes and is involved in a number of cellular processes, including cell signaling, apoptosis (programmed cell death), and the release of neurotransmitters.


Catalog Number I008752
CAS Number 51446-62-9
Synonyms

Phosphatidylserine; Distearoyl phosphatidylserine; Phosphatidylserine(36:0); Dioctadecanoylphosphatidylserine; C42H82NO10P; CHEBI:84519; HMDB12378;;(2S)-2-amino-3-[[(2R)-2,3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid

Molecular Formula C42H82NO10P
Purity ≥95%
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
IUPAC Name (2S)-2-amino-3-[[(2R)-2,3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid
InChI InChI=1S/C42H82NO10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49)/t38-,39+/m1/s1
InChIKey TZCPCKNHXULUIY-RGULYWFUSA-N
SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC
Reference

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1:Mining of a phospholipase D and its application in enzymatic preparation of phosphatidylserine. Zhou WB, Gong JS, Hou HJ, Li H, Lu ZM, Xu HY, Xu ZH, Shi JS.Bioengineered. 2017 May 16:1-10. doi: 10.1080/21655979.2017.1308992. [Epub ahead of print] PMID: 28509615<br />
2:Involvement of a putative substrate binding site in the biogenesis and assembly of phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae. Di Bartolomeo F, Doan KN, Athenstaedt K, Becker T, Daum G.Biochim Biophys Acta. 2017 Jul;1862(7):716-725. doi: 10.1016/j.bbalip.2017.04.007. Epub 2017 May 1. PMID: 28473294<br />
3:Stereochemistry- and Concentration-Dependent Effects of Phosphatidylserine Enrichment on Platelet Function. Meyer AF, Gruba SM, Kim D, Meyer BM, Koseoglu S, Dalluge JJ, Haynes CL.Biochim Biophys Acta. 2017 May 1. pii: S0005-2736(17)30144-X. doi: 10.1016/j.bbamem.2017.04.027. [Epub ahead of print] PMID: 28472616<br />
4:Specific phospholipid scramblases are involved in exposure of phosphatidylserine, an /eat-me/ signal for phagocytes, on degenerating axons. Wakatsuki S, Araki T.Commun Integr Biol. 2017 Feb 17;10(2):e1296615. doi: 10.1080/19420889.2017.1296615. eCollection 2017. PMID: 28451058 Free PMC Article<br />
5:Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O/&#39;Donnell VB, Harwood JL, Sabroe I, Parker LC.Mucosal Immunol. 2017 May;10(3):829. doi: 10.1038/mi.2017.40. No abstract available. PMID: 28435153<br />
6:IgM antibodies to oxidized phosphatidylserine as protection markers in cardiovascular disease among 60-year olds. Frosteg&aring;rd J, Su J, Sing S, Hua X, Vikstr&ouml;m M, Leander K, Gigante B, de Faire U, Frosteg&aring;rd AG.PLoS One. 2017 Apr 21;12(4):e0171195. doi: 10.1371/journal.pone.0171195. eCollection 2017. PMID: 28430795 Free PMC Article<br />
7:Inhibitory effects of ethyl pyruvate on platelet aggregation and phosphatidylserine exposure. Li W, Yang X, Peng M, Li C, Mu G, Chen F.Biochem Biophys Res Commun. 2017 Jun 3;487(3):560-566. doi: 10.1016/j.bbrc.2017.04.087. Epub 2017 Apr 18. PMID: 28427942<br />
8:Phosphatidylserine Translocation after Radiosurgery in an Animal Model of Arteriovenous Malformation. Rad NR, McRobb LS, Zhao Z, Lee VS, Patel NJ, Qureshi AS, Grace M, McHattan JJ, Raj JVA, Duong H, Kashba SR, Stoodley MA.Radiat Res. 2017 Apr 17. doi: 10.1667/RR14646.1. [Epub ahead of print] PMID: 28414573<br />
9:Young steady-state rabbit platelets do not have an enhanced capacity to expose procoagulant phosphatidylserine. Reddy EC, Wang H, Bang KW, Packham MA, Rand ML.Platelets. 2017 Apr 13:1-7. doi: 10.1080/09537104.2017.1295434. [Epub ahead of print] PMID: 28406717<br />
10:Phosphatidylserine Lateral Organization Influences the Interaction of Influenza Matrix Protein 1 with Lipid Membranes. Bobone S, Hilsch M, Storm J, Dunsing V, Herrmann A, Chiantia S.J Virol. 2017 Mar 29. pii: JVI.00267-17. doi: 10.1128/JVI.00267-17. [Epub ahead of print] PMID: 28356535

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