Phosphoglycolic acid lithium

• CAT Number: I040050
• Molecular Formula: C2H5O6P.xLi
• Molecular Weight: 156.03 (free acid)
• Purity: ≥95%

Phosphoglycolic acid (lithium) is a competitive inhibitor of phosphoglycerate mutase (PGAM)-B, an enzyme of the glycolytic pathway. Phosphoglycolic acid increases basal and fMLF-induced levels of G6P in intact neutrophils. Phosphoglycolic acid thereby increases upstream intermediates in neutrophils, thereby amplifying the respiratory oxidative burst[1].

Reference

[1]. Shalom-Barak T, et al. A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase. J Biol Chem. 2002 Oct 25;277(43):40659-65.
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