Phosphoramide mustard(CAT: M123069) is an active metabolite of cyclophosphamide, a widely used chemotherapy drug. It plays a crucial role in the drug’s antineoplastic activity by causing DNA cross-linking, which leads to cell death, particularly in rapidly dividing cancer cells. Phosphoramide mustard forms covalent bonds with DNA, preventing the replication and transcription of genetic material, thus inhibiting cell division and promoting apoptosis. It is used in the treatment of various cancers, including lymphomas, leukemia, and solid tumors. While effective, phosphoramide mustard is also associated with toxic side effects, as it can affect both cancerous and healthy cells.
| Catalog Number | M123069 |
| CAS Number | 10159-53-2 |
| Synonyms | phosphoramide mustard |
| Molecular Formula | C4H11Cl2N2O2P |
| Purity | ≥95% |
| Storage | Desiccate at -20C |
| IUPAC Name | amino-[bis(2-chloroethyl)amino]phosphinic acid |
| InChI | InChI=1S/C4H11Cl2N2O2P/c5-1-3-8(4-2-6)11(7,9)10/h1-4H2,(H3,7,9,10) |
| InChIKey | RJXQSIKBGKVNRT-UHFFFAOYSA-N |
| SMILES | C(CCl)N(CCCl)P(=O)(N)O |
