PhosTAC3

• CAT Number: I042368
• Molecular Formula: C50H71ClN2O13
• Molecular Weight: 943.56
• Purity: ≥95%
• Synonyms: [(1R)-1-[3-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
• InChI: InChI=1S/C50H71ClN2O13/c1-7-40(38-33-45(59-4)48(61-6)46(34-38)60-5)49(55)53-24-12-10-17-41(53)50(56)66-42(20-18-36-19-21-43(57-2)44(31-36)58-3)37-15-14-16-39(32-37)65-35-47(54)52-23-26-63-28-30-64-29-27-62-25-13-9-8-11-22-51/h14-16,19,21,31-34,40-42H,7-13,17-18,20,22-30,35H2,1-6H3,(H,52,54)/t40-,41-,42+/m0/s1
• InChIKey: URAXYIMEKGUPKY-WTQYMLSTSA-N
• SMILES: CC[C@@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCC(=O)NCCOCCOCCOCCCCCCCl

PhosTAC3（Cat No:I042368）is a small molecule compound that belongs to the class of phospho-targeting chimeric degraders, designed to selectively degrade specific target proteins within cells. It functions by recruiting target proteins to an E3 ubiquitin ligase via a phospho-epitope recognition, leading to ubiquitination and subsequent proteasomal degradation. PhosTAC3 is being investigated for its potential to selectively degrade proteins involved in various diseases, such as cancer and neurodegenerative disorders. This approach offers a promising strategy for targeting previously “undruggable” proteins, potentially advancing the development of novel therapeutic options.