PhosTAC5

• CAT Number: I042367
• Molecular Formula: C54H79ClN2O15
• Molecular Weight: 1031.66
• Purity: ≥95%
• Synonyms: [(1R)-1-[3-[2-[2-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
• InChI: InChI=1S/C54H79ClN2O15/c1-7-44(42-37-49(63-4)52(65-6)50(38-42)64-5)53(59)57-24-12-10-17-45(57)54(60)72-46(20-18-40-19-21-47(61-2)48(35-40)62-3)41-15-14-16-43(36-41)71-39-51(58)56-23-26-67-28-30-69-32-34-70-33-31-68-29-27-66-25-13-9-8-11-22-55/h14-16,19,21,35-38,44-46H,7-13,17-18,20,22-34,39H2,1-6H3,(H,56,58)/t44-,45-,46+/m0/s1
• InChIKey: FTAFLPQGXRIKMF-WVUVGWLZSA-N
• SMILES: CC[C@@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCC(=O)NCCOCCOCCOCCOCCOCCCCCCCl

PhosTAC5（Cat No.:I042367）is a novel, small molecule compound that functions as a phospho-targeting chimeric degrader, designed to selectively degrade target proteins by recruiting them to the cellular proteasome for degradation. It operates by linking a specific phospho-epitope on the target protein to an E3 ubiquitin ligase, facilitating its degradation. PhosTAC5 is being explored for its potential in targeting proteins involved in various diseases, including cancer and neurodegenerative disorders, by disrupting critical signaling pathways. Its targeted degradation approach offers a promising strategy for modulating protein levels and developing new therapeutic agents.