Phthalazinone pyrazole

• CAT Number: R049577
• CAS Number: 880487-62-7
• Molecular Formula: C18H15N5O
• Molecular Weight: 317.35
• Purity: ≥95%
• Synonyms: 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone
• Target: Epigenetics
• Storage: -20°C
• IUPAC Name: 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one
• InChI: InChI=1S/C18H15N5O/c1-12-11-16(21-20-12)19-17-14-9-5-6-10-15(14)18(24)23(22-17)13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22)
• InChIKey: DSDIWWSXOOXFSI-UHFFFAOYSA-N
• SMILES: CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)C4=CC=CC=C4

Phthalazinone pyrazole（Cat No.:R049577）is a small molecule inhibitor that targets poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair. By inhibiting PARP activity, Phthalazinone pyrazole interferes with the repair of single-strand DNA breaks, leading to cell death, particularly in cancer cells with deficient homologous recombination repair pathways, such as BRCA-mutant cancers. This compound is of interest in cancer therapy as it enhances the efficacy of DNA-damaging agents and is explored for its potential to treat cancers reliant on PARP for survival. Its selectivity makes it valuable in precision oncology research.

Reference

1.Moore, A.S.,Blagg, J.,Linardopoulos, S., et al. Aurora kinase inhibitors: Novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias. Leukemia 24(4), 671-678 (2010).