For research use only. Not for therapeutic Use.
PHTPP (CAT: I010602) is a selective estrogen receptor beta (ERβ) antagonist. It exhibits a 36-fold selectivity for ERβ over ERα, which are two subtypes of estrogen receptors. PHTPP demonstrates full antagonism at ERβ in a cotransfection assay using human endometrial cancer cells (HEC-1), while showing minimal effects on ERα. This selectivity makes PHTPP a valuable tool for studying the specific functions and signaling pathways mediated by ERβ.
| Catalog Number | I010602 |
| CAS Number | 805239-56-9 |
| Synonyms | 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol |
| Molecular Formula | C20H11F6N3O |
| Purity | ≥95% |
| Target | Estrogen Receptor/ERR |
| Solubility | Soluble to 33 mM in DMSO and to 100 mM in ethanol |
| Storage | Store at RT |
| InChIKey | AEZPAUSGTAHLOQ-UHFFFAOYSA-N |
