Physcion

• CAT Number: R011047
• CAS Number: 521-61-9
• Molecular Formula: C16H12O5
• Molecular Weight: 284.26
• Purity: ≥95%
• Synonyms: 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione; 6-Methoxychrysophanic Acid; 1,8-Dihydroxy-3-methyl-6-methoxyanthraquinone; 6-O-Methylemodin; Emodin 3-Methyl Ether; NSC 251670; Parietin; Rheochrysidin
• Target: Bacterial
• Storage: 3 years -20C powder
• IUPAC Name: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
• InChI: InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
• InChIKey: FFWOKTFYGVYKIR-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)OC

Physcion（Cat No.:R011047）is a naturally occurring anthraquinone compound found in several plants, including Rheum rhaponticum and Polygonum multiflorum. It exhibits a wide range of biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. Physcion has been studied for its potential in cancer therapy, where it demonstrates anticancer effects by inducing apoptosis and inhibiting cell proliferation. Additionally, it shows promise in treating metabolic disorders and cardiovascular diseases. Its mechanism of action is attributed to its ability to modulate key cellular pathways, making it a valuable compound for further pharmacological investigations.

Reference

1:Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370. Pan X, Wang H, Tong D, Wang C, Sun L, Zhao C, Li Y, Zhu L, Wu D.Am J Cancer Res. 2016 Dec 1;6(12):2919-2931. eCollection 2016. PMID: 28042511 Free PMC Article2:Upregulating miR-146a by physcion reverses multidrug resistance in human chronic myelogenous leukemia K562/ADM cells. Liu W, He J, Yang Y, Guo Q, Gao F.Am J Cancer Res. 2016 Nov 1;6(11):2547-2560. eCollection 2016. PMID: 27904770 Free PMC Article3:Physcion 8-O-β-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells. Wang Q, Wang Y, Xing Y, Yan Y, Guo P, Zhuang J, Qin F, Zhang J.Biomed Pharmacother. 2016 Oct;83:372-380. doi: 10.1016/j.biopha.2016.06.045. Epub 2016 Jul 14. PMID: 27416558 4:Physcion 8-O-β-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1. Chen X, Guo H, Li F, Fan D.Pharmacol Rep. 2017 Feb;69(1):36-44. doi: 10.1016/j.pharep.2016.09.012. Epub 2016 Sep 13. PMID: 27768961 5:Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Pang MJ, Yang Z, Zhang XL, Liu ZF, Fan J, Zhang HY.Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640. doi: 10.1038/aps.2016.98. Epub 2016 Oct 3. PMID: 27694907 Free PMC Article6:Upregulation of miR-124 by physcion 8-O-β-glucopyranoside inhibits proliferation and invasion of malignant melanoma cells via repressing RLIP76. Zhang D, Han Y, Xu L.Biomed Pharmacother. 2016 Dec;84:166-176. doi: 10.1016/j.biopha.2016.09.022. Epub 2016 Sep 19. PMID: 27657824 7:Upregulation of Human ST8Sia VI (α2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells. Yoon HK, An HK, Ko MJ, Kim KS, Mun SW, Kim DH, Kim CM, Kim CH, Choi YW, Lee YC.Int J Mol Sci. 2016 Aug 2;17(8). pii: E1246. doi: 10.3390/ijms17081246. PMID: 27490539 Free PMC Article8:EMMPRIN, SP1 and microRNA-27a mediate physcion 8-O-β-glucopyranoside-induced apoptosis in osteosarcoma cells. Wang Z, Yang H.Am J Cancer Res. 2016 Jun 1;6(6):1331-44. eCollection 2016. PMID: 27429847 Free PMC Article9:Anti-proliferative Effect of Physcion on Human Gastric Cell Line via Inducing ROS-Dependent Apoptosis. Xiong Y, Ren L, Wang Z, Hu Z, Zhou Y.Cell Biochem Biophys. 2015 Nov;73(2):537-543. doi: 10.1007/s12013-015-0674-9. PMID: 27352350 10:Transcriptomic analysis reveals distinct resistant response by physcion and chrysophanol against cucumber powdery mildew. Li Y, Tian S, Yang X, Wang X, Guo Y, Ni H.PeerJ. 2016 May 17;4:e1991. doi: 10.7717/peerj.1991. eCollection 2016. PMID: 27231648 Free PMC Article