Physostigmine-d3

• CAT Number: R006820
• CAS Number: 1217704-11-4
• Molecular Formula: C15H21N3O2
• Molecular Weight: 278.37
• Purity: ≥95%
• Synonyms: (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol Methylcarbamate Ester-d3; Eserine-d3; Synapton-d3
• Storage: Store at RT
• IUPAC Name: [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-(trideuteriomethyl)carbamate
• InChI: InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1/i2D3
• InChIKey: PIJVFDBKTWXHHD-RMLXDGKTSA-N
• SMILES: [2H]C([2H])([2H])NC(=O)OC1=CC2=C(C=C1)N([C@@H]3[C@]2(CCN3C)C)C

Physostigmine-d3 is a deuterated analog of physostigmine, a potent cholinesterase inhibitor used primarily in the treatment of glaucoma and for reversing anticholinergic toxicity. The incorporation of three deuterium atoms enhances the stability of the compound, making it particularly valuable in pharmacokinetic studies, isotope-labeled research, and drug metabolism investigations. This high-purity, isotopically labeled compound is essential for precise and accurate analytical measurements in both in vitro and in vivo studies. Physostigmine-d3 is an indispensable tool in the development of therapeutic agents targeting the cholinergic system and for studying drug-drug interactions.