Physostigmine Salicylate

• CAT Number: R060722
• CAS Number: 57-64-7
• Molecular Formula: C22H27N3O5
• Molecular Weight: 413.47
• Purity: ≥95%
• Synonyms: 2-Hydroxybenzoic Acid compd. with (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate; , 2-Hydroxybenzoic acid, compd. with (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbam
• Target: Cholinesterase (ChE)
• Storage: Store at -20 C
• IUPAC Name: [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate;2-hydroxybenzoic acid
• InChI: InChI=1S/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/m1./s1
• InChIKey: HZOTZTANVBDFOF-PBCQUBLHSA-N
• SMILES: CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.C1=CC=C(C(=C1)C(=O)O)O

Physostigmine Salicylate(CAT: R060722) is a reversible cholinesterase inhibitor used primarily in the treatment of glaucoma, Alzheimer’s disease, and anticholinergic toxicity. By inhibiting the enzyme acetylcholinesterase, Physostigmine increases the levels of acetylcholine in the synaptic cleft, enhancing cholinergic neurotransmission. This makes it particularly effective in reversing the effects of anticholinergic agents in cases of overdose or poisoning. Additionally, it has been used in some cases to improve cognitive function in Alzheimer’s patients by modulating neurotransmitter levels. The salicylate form improves the solubility of Physostigmine, making it easier to administer in medical applications. Due to its potent activity, it is used under careful medical supervision.