PI-273

• CAT Number: I017906
• CAS Number: 925069-34-7
• Molecular Formula: C₁₆H₁₆ClN₃O₂S₂
• Molecular Weight: 381.90
• Purity: ≥95%
• Target: Apoptosis
• Storage: Store at -20°C
• IUPAC Name: 2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide
• InChI: InChI=1S/C16H16ClN3O2S2/c1-3-11-8(2)24-15(12(11)13(18)21)20-16(23)19-14(22)9-4-6-10(17)7-5-9/h4-7H,3H2,1-2H3,(H2,18,21)(H2,19,20,22,23)
• InChIKey: MIERMBQDBLFAFW-UHFFFAOYSA-N
• SMILES: CCC1=C(SC(=C1C(=O)N)NC(=S)NC(=O)C2=CC=C(C=C2)Cl)C

PI-273（Cat No.:I017906）is a selective inhibitor of the interaction between the protein p53 and its negative regulator, MDM2. By inhibiting this interaction, PI-273 reactivates p53, a tumor suppressor protein that plays a key role in regulating cell cycle arrest and apoptosis. This reactivation leads to enhanced p53 activity, promoting cancer cell death and preventing tumor progression. PI-273 is particularly valuable in research focused on cancers with overexpressed MDM2, where p53 function is often compromised. Its targeted mechanism offers potential for novel cancer therapies aimed at restoring p53’s tumor-suppressive functions.

Reference

[1]. Li J, et al. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6253-6266.