PI-3065

• CAT Number: I005659
• CAS Number: 955977-50-1
• Molecular Formula: C27H31FN6OS
• Molecular Weight: 506.644
• Purity: ≥95%
• Synonyms: PI3065；PI 3065；
• Target: PI3K
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 15 nM
• IUPAC Name: 4-[6-[[4-(cyclopropylmethyl)piperazin-1-yl]methyl]-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl]morpholine
• InChI: InChI=1S/C27H31FN6OS/c28-21-3-4-22-20(5-6-29-22)24(21)26-30-23-15-19(17-33-9-7-32(8-10-33)16-18-1-2-18)36-25(23)27(31-26)34-11-13-35-14-12-34/h3-6,15,18,29H,1-2,7-14,16-17H2
• InChIKey: YDNOHCOYQVZOMC-UHFFFAOYSA-N
• SMILES: C1CC1CN2CCN(CC2)CC3=CC4=C(S3)C(=NC(=N4)C5=C(C=CC6=C5C=CN6)F)N7CCOCC7

PI-3065 (Cat.No:I005659) is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR. 

Reference

[1]. Ali K, et al. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 19;509(7505):407-11.