AS-605240

• CAT Number: I004441
• CAS Number: 648450-29-7
• Molecular Formula: C₁₂H₇N₃O₂S
• Molecular Weight: 257.27
• Purity: ≥95%
• Synonyms: (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
• Target: PI3K
• Solubility: DMSO: ≤ 5.8 mg/mL (Need warming)
• Storage: 2-8°C
• IC50: 8 nM
• IUPAC Name: (5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
• InChI: InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6+
• InChIKey: SQWZFLMPDUSYGV-UXBLZVDNSA-N
• SMILES: C1=CC2=NC=CN=C2C=C1/C=C/3\C(=O)NC(=O)S3

AS-605240（Cat No.:I004441）is a potent and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ), an enzyme involved in the regulation of immune cell function, inflammation, and cancer progression. By specifically targeting PI3Kγ, AS-605240 inhibits the signaling pathways responsible for leukocyte recruitment and activation, making it a valuable tool in studies related to inflammatory diseases and cancer. Preclinical research has shown its potential in reducing inflammation in conditions like rheumatoid arthritis and in inhibiting tumor growth by modulating the immune microenvironment, positioning it as a promising candidate for therapeutic development.

Reference

1:Circ Res. 2010 Jul 23;107(2):e5; author reply e6-7. doi: 10.1161/CIRCRESAHA.110.224568. Effects of PI3Kgamma inhibition using AS-605240 in acute myocardial infarction.Seropian IM,Toldo S,Abbate A,Mezzaroma E,Van Tassell BW, PMID: 20651289 DOI: 10.1161/CIRCRESAHA.110.224568