PI3K(delta)-IN-2

• CAT Number: I013395
• CAS Number: 1702816-75-8
• Molecular Formula: C₂₈H₃₇FN₆O₅S
• Molecular Weight: 588.69
• Purity: ≥95%
• Target: PI3K
• Solubility: DMSO: 10 mM
• IUPAC Name: N-[5-[6-fluoro-8-[[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl]-2-morpholin-4-ylquinazolin-4-yl]-2-methoxypyridin-3-yl]methanesulfonamide
• InChI: InChI=1S/C28H37FN6O5S/c1-28(2,36)20-5-7-34(8-6-20)17-19-13-21(29)15-22-24(31-27(32-25(19)22)35-9-11-40-12-10-35)18-14-23(33-41(4,37)38)26(39-3)30-16-18/h13-16,20,33,36H,5-12,17H2,1-4H3
• InChIKey: NVWKNQGHVMMAJW-UHFFFAOYSA-N
• SMILES: CC(C)(C1CCN(CC1)CC2=C3C(=CC(=C2)F)C(=NC(=N3)N4CCOCC4)C5=CC(=C(N=C5)OC)NS(=O)(=O)C)O

PI3Kδ-IN-2 (Cat.No:I013395) is a potent and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1, compound 10; has an IC50 of 6.4 nM.

Reference

[1]. WO 2015055071 A1