For research use only. Not for therapeutic Use.
PI4K-IN-1 (CAT: I022786) is a potent and selective inhibitor of phosphatidylinositol 4-kinases, specifically targeting PI4KIIIα and PI4KIIIβ, with pIC₅₀ values of 9.0 and 6.6, respectively. These kinases are key regulators of phosphoinositide signaling pathways involved in membrane trafficking, lipid metabolism, and viral replication. PI4K-IN-1 is widely used in biochemical and cell-based studies to dissect the roles of PI4KIII isoforms in cellular signaling, and it shows promise in antiviral research due to the essential role of PI4KIIIα in the replication of certain RNA viruses.
| CAS Number | 1800017-49-5 |
| Synonyms | 4-[[[6-[1-(cyclopropylmethyl)-2-oxopyridin-4-yl]-1,3-benzothiazol-2-yl]amino]methyl]cyclohexane-1-carboxylic acid |
| Molecular Formula | C24H27N3O3S |
| Purity | ≥95% |
| IUPAC Name | 4-[[[6-[1-(cyclopropylmethyl)-2-oxopyridin-4-yl]-1,3-benzothiazol-2-yl]amino]methyl]cyclohexane-1-carboxylic acid |
| InChI | InChI=1S/C24H27N3O3S/c28-22-12-19(9-10-27(22)14-16-1-2-16)18-7-8-20-21(11-18)31-24(26-20)25-13-15-3-5-17(6-4-15)23(29)30/h7-12,15-17H,1-6,13-14H2,(H,25,26)(H,29,30) |
| InChIKey | LCUPEZBPGVQFLN-UHFFFAOYSA-N |
| SMILES | C1CC(CCC1CNC2=NC3=C(S2)C=C(C=C3)C4=CC(=O)N(C=C4)CC5CC5)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
