Piboserod hydrochloride

• CAT Number: I002311
• CAS Number: 178273-87-5
• Molecular Formula: C22H32ClN3O2
• Molecular Weight: 405.96
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 50 mM in water(water soluble)
• Storage: 3 years -20C powder
• InChI: InChI=1S/C22H31N3O2.ClH/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25;/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26);1H
• InChIKey: UABVCZHWRUGYSR-UHFFFAOYSA-N
• SMILES: O=C(C1=C(OCCC2)N2C3=C1C=CC=C3)NCC4CCN(CCCC)CC4.[H]Cl

Piboserod hydrochloride (Cat.No:I002311) is a selective antagonist of the 5-HT4 serotonin receptor. It has been studied for its potential application in the treatment of gastrointestinal disorders, specifically for improving gastrointestinal motility. Piboserod hydrochloride exhibits prokinetic effects and has shown promise in clinical trials for the management of conditions like chronic constipation and gastroparesis.

Reference

[1]. Darblade B, et al. Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle. World J Urol. 2005 Jun;23(2):147-51.

[2]. Kjekshus JK, et al. Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. Eur J Heart Fail. 2009 Aug;11(8):771-8.

[3]. Nirogi R, et al. In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145. J Pharm Pharmacol. 2013 May;65(5):704-12.