For research use only. Not for therapeutic Use.
Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
| Catalog Number | I034728 |
| CAS Number | 154889-68-6 |
| Synonyms | Pibrozelesin; KW 2189; KW-2189; KW2189; |
| Molecular Formula | C32H36BrN5O8 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic acid, 8-(bromomethyl)-3,6,7,8-tetrahydro-2-methyl-4-(((4-methyl-1-piperazinyl)carbonyl)oxy)-6-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester, (S)- |
| InChI | InChI=1S/C32H36BrN5O8/c1-16-23(31(40)45-6)25-24-18(14-33)15-38(20(24)13-21(27(25)34-16)46-32(41)37-9-7-36(2)8-10-37)30(39)19-11-17-12-22(42-3)28(43-4)29(44-5)26(17)35-19/h11-13,18,34-35H,7-10,14-15H2,1-6H3/t18-/m1/s1 |
| InChIKey | QRMNENFZDDYDEF-GOSISDBHSA-N |
| SMILES | O=C(C1=C(C)NC2=C(OC(N3CCN(C)CC3)=O)C=C4N(C(C(N5)=CC6=C5C(OC)=C(OC)C(OC)=C6)=O)C[C@@H](CBr)C4=C21)OC |
