Piceatannol

• CAT Number: I000099
• CAS Number: 10083-24-6
• Molecular Formula: C14H12O4
• Molecular Weight: 244.24
• Purity: ≥95%
• Synonyms: 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
• Target: IκB/IKK
• Solubility: Soluble in DMSO to 100 mM and in ethanol to 100 mM
• Storage: 3 years -20C powder
• InChI: InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
• InChIKey: CDRPUGZCRXZLFL-OWOJBTEDSA-N
• SMILES: C1=CC(=C(C=C1/C=C/C2=CC(=CC(=C2)O)O)O)O

Piceatannol (Cat No.:I000099) is a naturally occurring stilbenoid compound found in various plants, including grapes, passion fruit, and peanuts. It exhibits diverse pharmacological activities by targeting specific molecular pathways. Piceatannol has been shown to act as a potent inhibitor of the enzyme tyrosine kinase, thereby blocking signaling pathways involved in cell growth and proliferation. This makes it a potential candidate for cancer treatment, particularly in inhibiting the growth of cancer cells. Additionally, piceatannol demonstrates anti-inflammatory effects by inhibiting various inflammatory mediators. Its antioxidant activity helps protect against oxidative stress-related damage. Piceatannol’s multifaceted pharmacological properties and target-specific actions make it a promising compound for further research and therapeutic applications.

Reference

[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7.
[2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.