For research use only. Not for therapeutic Use.
Picloxydine is a heterocyclic biguanide with antibacterial and antiplaque activity.
0.4% Picloxydine produces a highly significant drop in the number of aerobic organisms. 0.4% Picloxydine is far more effective than 0.2% Picloxydine or chlorhexidine in reducing the total viable count of oral aerobic and anaerobic organisms[1]. Picloxydine is also used in eye drops in the topical therapy of trachoma[2].
| Catalog Number | I013364 |
| CAS Number | 5636-92-0 |
| Synonyms | 1-N’,4-N’-bis[N’-(4-chlorophenyl)carbamimidoyl]piperazine-1,4-dicarboximidamide |
| Molecular Formula | C20H24Cl2N10 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H24Cl2N10/c21-13-1-5-15(6-2-13)27-17(23)29-19(25)31-9-11-32(12-10-31)20(26)30-18(24)28-16-7-3-14(22)4-8-16/h1-8H,9-12H2,(H4,23,25,27,29)(H4,24,26,28,30) |
| InChIKey | YNCLPFSAZFGQCD-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1C(=NC(=NC2=CC=C(C=C2)Cl)N)N)C(=NC(=NC3=CC=C(C=C3)Cl)N)N |
| Reference | [1]. Newcomb GM, et al. An in vivo comparison of chlorhexidine and picloxydine mouthrinses: a possible association between chemical structure and antiplaque activity. J Periodontol. 1977 May;48(5):282-4. [2]. Obikili AG, et al. A double-blind comparison of picloxydine dihydrochloride (Vitabact eye drops) and sulfacetamide eye drops in the topical therapy of trachoma. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1988;65(3-4):119-32. |
