piCRAC-1

• CAT Number: I043671
• CAS Number: 2418049-54-2
• Molecular Formula: C17H10F6N4
• Molecular Weight: 384.28
• Purity: ≥95%
• Synonyms: (2,6-difluorophenyl)-[1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]diazene
• InChI: InChI=1S/C17H10F6N4/c18-12-4-1-3-11(17(21,22)23)10(12)9-27-8-7-15(26-27)24-25-16-13(19)5-2-6-14(16)20/h1-8H,9H2
• InChIKey: TXWNZTPRPAPHSE-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1)F)CN2C=CC(=N2)N=NC3=C(C=CC=C3F)F)C(F)(F)F

piCRAC-1 is a potent, photoinducible Ca2+ release-activated Ca2+ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage[1].

Reference

[1]. Yang X, et al. Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles. J Am Chem Soc. 2020 May 20;142(20):9460-9470.
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