For research use only. Not for therapeutic Use.
Picrotin is an active compound, also is one of the composition of picrotoxin (an antagonist of GABAA receptors (GABAARs) and glycine receptors (GlyRs)). Picrotin has sensitivity for GlyRs/b> with IC50 values range from 5.2 μM to 106 μM. Picrotin can be used for the research of neurotransmission[1][2].
Picrotin has sensitivity for α2 GlyRs with IC50 value of 13.1 μM[1].
| Catalog Number | R067041 |
| CAS Number | 21416-53-5 |
| Molecular Formula | C15H18O7 |
| Purity | ≥95% |
| Reference | [1]. Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9. [2]. Dian-Shi Wang, et al. Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors. J Biol Chem. 2007 Jun 1;282(22):16016-35. |
