Pifithrin-α, Cyclic, hydrobromide

• CAT Number: I003832
• CAS Number: 511296-88-1
• Molecular Formula: C₁₆H₁₆N₂S ∙ HBr
• Molecular Weight: 349.29
• Purity: ≥95%
• Synonyms: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide
• Target: MDM-2/p53
• Solubility: DMSO: ≤ 26 mg/mL
• Storage: Desiccate at RT
• IC50: 23 uM(IGROV-1 cell line) [1]
• InChI: InChI=1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13;/h6-10H,2-5H2,1H3;1H
• InChIKey: SGNCOAOESGSEOP-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br

Pifithrin-α, Cyclic, hydrobromide (Cat.No:I003832) is a cyclic form of Pifithrin-α, a small molecule inhibitor of p53-mediated transcriptional activation. It blocks the interaction between p53 and its downstream target proteins. Pifithrin-α, Cyclic, hydrobromide is commonly used in research to study p53-related cellular processes and potential therapeutic interventions in cancer and neurodegenerative diseases.

Reference

[1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57.
[2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83.