For research use only. Not for therapeutic Use.
PI3K p110α specific inhibitor; IC50 values (nM): 7.8 (p110α), 343 (p110β), 907 (p110δ) (Chaussade et al reported).
KEYWORDS: PIK 75 hydrochloride | supplier | PI3K p110α inhibitor | PIK 75 hydrochloride | PIK75 hydrochloride | CAS [1462995-14-7] | [945619-31-8] | Phosphatidylinositol | PI3K | Inhibitor | Insulin Signaling | Enzymes
| Catalog Number | I047529 |
| CAS Number | 1462995-14-7 |
| Molecular Formula | C16H14BrN5O4S.HCl |
| Purity | ≥95% |
| IUPAC Name | N-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide;hydrochloride |
| InChI | InChI=1S/C16H14BrN5O4S.ClH/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16;/h3-10H,1-2H3;1H/b19-9+; |
| SMILES | CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl |
| Reference | ZA Knight et al. A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling. Cell 2006, 125, 733–747.
C Chaussade et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007, 404(3), 449–458.
S Kim et al. Insulin-like growth factor-1 regulates platelet activation through PI3-Kα isoform. Blood, 2007, 110(13), 4206-4213. |
