Pilsicainide hydrochloride

• CAT Number: I008764
• CAS Number: 88069-49-2
• Molecular Formula: C17H25ClN2O
• Molecular Weight: 308.85
• Purity: ≥95%
• Synonyms: N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide;hydrochloride
• InChI: InChI=1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H
• InChIKey: NZOSVDHCTCLGEB-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)C)NC(=O)CC23CCCN2CCC3.Cl

Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent[1][2].
Pilsicainide hydrochloride (SUN-1165) (10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 ± 22.9 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1].
Pilsicainide hydrochloride (SUN-1165) (2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current[1].

Reference

[1]. Yamakawa M, et al. Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats. Thyroid. 2005 Jul;15(7):653-9.
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[2]. Plosker GL. Pilsicainide. Drugs. 2010 Mar 5;70(4):455-67.
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