PIM-447 dihydrochloride

• CAT Number: I002363
• CAS Number: 1820565-69-2
• Molecular Formula: C24H25Cl2F3N4O
• Molecular Weight: 513.38
• Purity: ≥95%
• Target: target: pan-PIM inhibitor
• Solubility: DMSO ≥ 50 mg/mL
• Storage: Store at -20°C
• IUPAC Name: N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide;dihydrochloride
• InChI: 1S/C24H23F3N4O.2ClH/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26;;/h2-8,12-15H,9-11,28H2,1H3,(H,31,32);2*1H/t13-,14+,15-;;/m0../s1
• InChIKey: BVRSHQQSBGCMJE-ALGQTRDQSA-N
• SMILES: C[C@H]1C[C@H](C[C@H](C1)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)F.Cl.Cl

PIM-447 dihydrochloride (Cat.No:I002363) is a selective inhibitor of PIM kinases, a family of serine/threonine kinases implicated in various cancers. PIM-447 has demonstrated potent antitumor activity by inhibiting cancer cell proliferation and promoting apoptosis. It is being studied for its therapeutic potential in hematological malignancies and solid tumors in preclinical and clinical settings.