For research use only. Not for therapeutic Use.
PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].
| Catalog Number | R029067 |
| CAS Number | 477845-12-8 |
| Synonyms | 4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidin-2-amine |
| Molecular Formula | C17H11ClN4O |
| Purity | ≥95% |
| InChI | InChI=1S/C17H11ClN4O/c18-12-4-1-10(2-5-12)16-13-9-11(3-6-15(13)22-23-16)14-7-8-20-17(19)21-14/h1-9H,(H2,19,20,21) |
| InChIKey | AQVFETGXIRKVAQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=C3C=C(C=CC3=NO2)C4=NC(=NC=C4)N)Cl |
| Reference | [1]. Pierce AC, Jacobs M, Stuver-Moody C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem. 2008 Mar 27;51(6):1972-5. |
